The struggle to find a drug that makes you so fast that you save more time taking it than you lose reading about it

Medication for brain performance enhancement. Anecdotally ubiquitous amongst the next cohort of my highly competitive field, and dotcom types. Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley is notorious. Also my brief contact with finance types leads me to believe it is common there. I am sure it is in many industries besides.

My advice on this is of course worthless, as I know nothing of pharmacology etc. But even if I did, I would not endorse the taking of performance enhancing drugs without professional medical and legal advice regarding your compliance with local governmental regime and its positioning/branding..

Assessing effectiveness of


DIY? “Neurohacker toolbox”. Scott Alexander speculates: Cognitive enhancers: mechanisms and tradeoffs. Relates to Gwern’s Drug Heuristics.

Aella, Are you just pushing the “insight” button? on taking LSD for the (feeling of?) insight.


SMBC on uppers


In practice, most nerds seem to take modafinil plus some other things. A profusion of sites with names like Nootropics Depot,, and and presumably suggest that doing this without prescription is pretty common. One might imagine it is a kind of ‘viagra for the brain’ niche that is being filled here. I am unclear how legal that is, nor how safe, nor how effective it would if it were safe and legal.


Is ISRIB any good?




Astrid, Nehlig. 2010. Is Caffeine a Cognitive Enhancer? Journal of Alzheimer’s Disease, no. S1: 85–94.
Chen, Ning, Mi Yang, Muke Zhou, Jing Xiao, Jian Guo, and Li He. 2017. L-carnitine for cognitive enhancement in people without cognitive impairment.” The Cochrane Database of Systematic Reviews 3 (March): CD009374.
Frank, Kurtis, Kamal Patel, Gregory Lopez, and Bill Willis. 2021. Alpha-GPC Research Analysis,” October.
Lopez, C. M., S. Govoni, F. Battaini, S. Bergamaschi, A. Longoni, C. Giaroni, and M. Trabucchi. 1991. Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine.” Pharmacology, Biochemistry, and Behavior 39 (4): 835–40.
Moran, Rosalyn J., Pablo Campo, Mkael Symmonds, Klaas E. Stephan, Raymond J. Dolan, and Karl J. Friston. 2013. Free Energy, Precision and Learning: The Role of Cholinergic Neuromodulation.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 33 (19): 8227–36.
Pepeu, G., and G. Spignoli. 1989. Nootropic drugs and brain cholinergic mechanisms.” Progress in Neuro-Psychopharmacology & Biological Psychiatry 13 Suppl: S77–88.
Rae, Caroline D., and Stefan Bröer. 2015. Creatine as a Booster for Human Brain Function. How Might It Work? Neurochemistry International 89 (October): 249–59.
Schindler, U. 1989. Pre-clinical evaluation of cognition enhancing drugs.” Progress in Neuro-Psychopharmacology & Biological Psychiatry 13 Suppl: S99–115.
Smith, A. 2005. Effects of Repeated Doses of Caffeine on Mood and Performance of Alert and Fatigued Volunteers.” Journal of Psychopharmacology 19 (6): 620–26.
Vossel, Simone, Markus Bauer, Christoph Mathys, Rick A. Adams, Raymond J. Dolan, Klaas E. Stephan, and Karl J. Friston. 2014. Cholinergic Stimulation Enhances Bayesian Belief Updating in the Deployment of Spatial Attention.” The Journal of Neuroscience 34 (47): 15735–42.

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