Alzheimers and the microbiome

Your digestive system eating your brain


Does tooth bacteria cause alzheimers

Who knows? I am not sure how settled this research is, but it could be an indicator that dental hygiene is a good thing to prioritise.

Gingivitis destroys your brain, according to this pop science article and its many journal reference, by enabling P. Gingivalis buildup and eventual brain damage through the “gingipains” they produce.

PR about Melbourne research into gingivitis vaccines.

This company gets some free publicity for their anti-gingipain- drugs.

Sanctimonious but sensible article about how to brush your teeth to minimise this nastiness.

Dominy, Stephen S., Casey Lynch, Florian Ermini, Malgorzata Benedyk, Agata Marczyk, Andrei Konradi, Mai Nguyen, et al. 2019. “Porphyromonas Gingivalis in Alzheimer’s Disease Brains: Evidence for Disease Causation and Treatment with Small-Molecule Inhibitors.” Science Advances 5 (1): eaau3333. https://doi.org/10.1126/sciadv.aau3333.

Fitzpatrick, Rebecca E, Lakshmi C Wijeyewickrema, and Robert N Pike. 2009. “The Gingipains: Scissors and Glue of the Periodontal Pathogen, Porphyromonas Gingivalis.” Future Microbiology 4 (4): 471–87. https://doi.org/10.2217/fmb.09.18.

Gatz, Margaret, James A. Mortimer, Laura Fratiglioni, Boo Johansson, Stig Berg, Chandra A. Reynolds, and Nancy L. Pedersen. 2006. “Potentially Modifiable Risk Factors for Dementia in Identical Twins.” Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 2 (2): 110–17. https://doi.org/10.1016/j.jalz.2006.01.002.

Ilievski, Vladimir, Paulina K. Zuchowska, Stefan J. Green, Peter T. Toth, Michael E. Ragozzino, Khuong Le, Haider W. Aljewari, Neil M. O’Brien-Simpson, Eric C. Reynolds, and Keiko Watanabe. 2018. “Chronic Oral Application of a Periodontal Pathogen Results in Brain Inflammation, Neurodegeneration and Amyloid Beta Production in Wild Type Mice.” PLOS ONE 13 (10): e0204941. https://doi.org/10.1371/journal.pone.0204941.

Ishida, Naoyuki, Yuichi Ishihara, Kazuto Ishida, Hiroyuki Tada, Yoshiko Funaki-Kato, Makoto Hagiwara, Taslima Ferdous, et al. 2017. “Periodontitis Induced by Bacterial Infection Exacerbates Features of Alzheimer’s Disease in Transgenic Mice.” Npj Aging and Mechanisms of Disease 3 (1). https://doi.org/10.1038/s41514-017-0015-x.

Noble, J M, L N Borrell, P N Papapanou, M S V Elkind, N Scarmeas, and C B Wright. 2009. “Periodontitis Is Associated with Cognitive Impairment Among Older Adults: Analysis of NHANES-III.” Journal of Neurology, Neurosurgery, and Psychiatry 80 (11): 1206–11. https://doi.org/10.1136/jnnp.2009.174029.

Poole, Sophie, Sim K. Singhrao, Sasanka Chukkapalli, Mercedes Rivera, Irina Velsko, Lakshmyya Kesavalu, and StJohn Crean. 2015. “Active Invasion of Porphyromonas Gingivalis and Infection-Induced Complement Activation in ApoE -/- Mice Brains.” Journal of Alzheimer’s Disease 43 (1): 67–80. https://doi.org/10.3233/JAD-140315.