Canalization and plasticity in human brains

Updating fast-system priors; therapy as described by mathematicians

April 9, 2022 — December 4, 2024

adaptive
cooperation
evolution
learning
mind
networks
utility
Figure 1

Perhaps one reason we do complicated things naïvely is that we do not notice when circumstances change, and in fact retain deep instincts calibrated to some lost past state of the world, and new information does not overspill in that deep-worn rut. A term of art for that wearing-a-groove-into-our-souls, is canalization. Mathematical models thereof have gotten some hype lately, so let us track some of teh ideas.

Is canalization an important concept for meditation? How about for maladaptive feelings? How can we decanalize something we do not want canalized?

Conversely, how do we canalize that which it benefit us to commit to? Maybe choosing this is how we commit to something that is in a sense arbitrary, but also important to commit to — like a relationship.

Canalization is the converse, I suppose, to neuro-plasticity, which is also a hot topic. And moving between states of plasticity and canalization seems to be sometimes called annealing.

Introduction: The Canal Papers - by Scott Alexander about Carhart-Harris et al. (2023)

1 Puberty

(Blakemore and Choudhury 2006; Carhart-Harris et al. 2023; Durston et al. 2006; Tyborowska et al. 2018) TBC.

2 Sex.

Maybe (Leuner, Glasper, and Gould 2010).

3 Matrescence

The brain rewriting mothers experience over childbirth (Orchard et al. 2023).

Figure 2: Pritschet et al. (2024) track the changes in grey matter volume across pregnancy in a single subject. Wowee, that’s a lot of brain volume going away. Why does it do that? What happens next?

4 Psychedelics

(Carhart-Harris and Friston 2019; Carhart-Harris et al. 2023) and (Nardou et al. 2019, 2023) argue that psychedelics can induce a state of plasticity in the brain that is normally only seen in puberty.

5 Love

See: What is Love? Neural Annealing in the Presence of an Intentional Object.

6 Incoming

See also the problem of growing up, messenger shooting.

Figure 3

7 References

Blakemore, and Choudhury. 2006. Brain development during puberty: state of the science.” Developmental science.
Carhart-Harris, Chandaria, Erritzoe, et al. 2023. Canalization and Plasticity in Psychopathology.” Neuropharmacology.
Carhart-Harris, and Friston. 2019. REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics.” Pharmacological Reviews.
Clark, Watson, and Friston. 2018. What Is Mood? A Computational Perspective.” Psychological Medicine.
Dick, Leech, Moses, et al. 2006. The interplay of learning and development in shaping neural organization.” Developmental science.
Durston, Davidson, Tottenham, et al. 2006. A shift from diffuse to focal cortical activity with development.” Developmental science.
Leuner, Glasper, and Gould. 2010. Sexual Experience Promotes Adult Neurogenesis in the Hippocampus Despite an Initial Elevation in Stress Hormones.” PLOS ONE.
Nardou, Lewis, Rothhaas, et al. 2019. Oxytocin-Dependent Reopening of a Social Reward Learning Critical Period with MDMA.” Nature.
Nardou, Sawyer, Song, et al. 2023. Psychedelics Reopen the Social Reward Learning Critical Period.” Nature.
Orchard, Rutherford, Holmes, et al. 2023. Matrescence: lifetime impact of motherhood on cognition and the brain.” Trends in Cognitive Sciences.
Petri, Expert, Turkheimer, et al. 2014. Homological Scaffolds of Brain Functional Networks.” Journal of The Royal Society Interface.
Pritschet, Taylor, Cossio, et al. 2024. Neuroanatomical Changes Observed over the Course of a Human Pregnancy.” Nature Neuroscience.
Tyborowska, Volman, Niermann, et al. 2018. Early-Life and Pubertal Stress Differentially Modulate Grey Matter Development in Human Adolescents.” Scientific Reports.