Bio marker tracking

We are probably not going to optimize ourselves out of mortality, but it feels good to try nonetheless



Quantified self for genes and blood (etc) chemistry. Personalised preventative medicine etc.

Theory

Frank Harrell - How to Do Bad Biomarker Research

Biomarker Uncertainty Principle: A molecular signature derived from high-dimensional data can be either parsimonious or predictive, but not both.

We have more data than ever, more good data than ever, a lower proportion of data that are good, a lack of strategic thinking about what data are needed to answer questions of interest, sub-optimal analysis of data, and an occasional tendency to do research that should not be done.

See also quantified self

Acquiring data

References

Gregory, Naina Sinha, Rekha Kumar, Emily M. Stein, Ellen Alexander, Paul Christos, Richard S. Bockman, and John S. Rodman. 2015. Potassium citrate decreases bone resorption in postmenopausal women with osteopenia: a randomized, double-blind clinical trial.” Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 21 (12): 1380–86.
Jehle, Sigrid, Henry N. Hulter, and Reto Krapf. 2013. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.” The Journal of Clinical Endocrinology and Metabolism 98 (1): 207–17.
Morales, A. J., R. H. Haubrich, J. Y. Hwang, H. Asakura, and S. S. Yen. 1998. The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.” Clinical Endocrinology 49 (4): 421–32.
Westerman, Kenneth, Ashley Reaver, Catherine Roy, Margaret Ploch, Erin Sharoni, Bartek Nogal, David A. Sinclair, David L. Katz, Jeffrey B. Blumberg, and Gil Blander. 2018. Longitudinal Analysis of Biomarker Data from a Personalized Nutrition Platform in Healthy Subjects.” Scientific Reports 8 (1): 14685.

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