Bio marker tracking

Instrumenting health to improve it

2022-01-11 — 2023-07-17

Wherein monthly serial blood panels and genomic markers are recorded and analyzed using personal-data tooling, and are used to inform quotidian fitness and personalised preventative regimens.

causality
drugs
faster pussycat
fit
gene
institutions
mind

Quantified self for genes and blood (etc.) chemistry. Personalised preventative medicine etc. I am mostly interested in quotidian health here, a.k.a. fitness. There are many other things that one might wish to moderate one’s blood chemistry for. Life extension looks specialised.

Figure 1

1 Theory

Frank Harrell, How to Do Bad Biomarker Research

Biomarker Uncertainty Principle: A molecular signature derived from high-dimensional data can be either parsimonious or predictive, but not both.

We have more data than ever, more good data than ever, a lower proportion of data that are good, a lack of strategic thinking about what data are needed to answer questions of interest, sub-optimal analysis of data, and an occasional tendency to do research that should not be done.

See also quantified self, personalized medicine.

2 Acquiring data

  • inside tracker seems to roll in some analytics for biomonitors, and also suggested interventions.
  • i-screen seems to be the easy one to use in Australia. Not outrageously expensive, merely annoyingly expensive.

3 Tools

4 Incoming

5 References

Campbell, Bellman, Stephenson, et al. 2017. “Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.” Ageing Research Reviews.
Gregory, Kumar, Stein, et al. 2015. “Potassium citrate decreases bone resorption in postmenopausal women with osteopenia: a randomized, double-blind clinical trial.” Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
Jehle, Hulter, and Krapf. 2013. “Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.” The Journal of Clinical Endocrinology and Metabolism.
Morales, Haubrich, Hwang, et al. 1998. “The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.” Clinical Endocrinology.
Skolmowska, Głąbska, Kołota, et al. 2022. “Effectiveness of Dietary Interventions to Treat Iron-Deficiency Anemia in Women: A Systematic Review of Randomized Controlled Trials.” Nutrients.
Westerman, Reaver, Roy, et al. 2018. “Longitudinal Analysis of Biomarker Data from a Personalized Nutrition Platform in Healthy Subjects.” Scientific Reports.