Quantified self for genes and blood (etc) chemistry. Personalised preventative medicine etc.
Theory
Frank Harrell, How to Do Bad Biomarker Research
Biomarker Uncertainty Principle: A molecular signature derived from high-dimensional data can be either parsimonious or predictive, but not both.
We have more data than ever, more good data than ever, a lower proportion of data that are good, a lack of strategic thinking about what data are needed to answer questions of interest, sub-optimal analysis of data, and an occasional tendency to do research that should not be done.
See also quantified self, personalized medicine.
Acquiring data
- inside tracker seems to roll in some analytics for biomonitors, and also suggested interventions.
- i-screen seems to be the easy one to use in Australia. Not outrageously expensive, merely annoyingly expensive.
Tools
Incoming
- markwk/awesome-biomarkers: Curated List of Biomarkers, Blood Tests, and Blood Tracking
- Iron deficiencies are very bad and you should treat them
- Does Metformin Work as an Anti-Aging Drug?
- If youβre diabetic, donβt wait for your smartwatch to replace your needles - The Verge
- Blood oxygen monitors face scrutiny from FDA panel - The Verge
References
Campbell, Jared M., Susan M. Bellman, Matthew D. Stephenson, and Karolina Lisy. 2017. βMetformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.β Ageing Research Reviews 40 (November): 31β44.
Gregory, Naina Sinha, Rekha Kumar, Emily M. Stein, Ellen Alexander, Paul Christos, Richard S. Bockman, and John S. Rodman. 2015. βPotassium citrate decreases bone resorption in postmenopausal women with osteopenia: a randomized, double-blind clinical trial.β Endocrine Practice: Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 21 (12): 1380β86.
Jehle, Sigrid, Henry N. Hulter, and Reto Krapf. 2013. βEffect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial.β The Journal of Clinical Endocrinology and Metabolism 98 (1): 207β17.
Morales, A. J., R. H. Haubrich, J. Y. Hwang, H. Asakura, and S. S. Yen. 1998. βThe effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.β Clinical Endocrinology 49 (4): 421β32.
Westerman, Kenneth, Ashley Reaver, Catherine Roy, Margaret Ploch, Erin Sharoni, Bartek Nogal, David A. Sinclair, David L. Katz, Jeffrey B. Blumberg, and Gil Blander. 2018. βLongitudinal Analysis of Biomarker Data from a Personalized Nutrition Platform in Healthy Subjects.β Scientific Reports 8 (1): 14685.
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